| 06 Apr 2021 21:00 | Manchester City | 2 : 1 | Borussia Dortmund | |
| 06 Apr 2021 21:00 | Real Madrid | 3 : 1 | Liverpool | |
| 07 Apr 2021 21:00 | Porto | 0 : 2 | Chelsea | |
| 07 Apr 2021 21:00 | Bayern Munich | 2 : 3 | PSG | |
| 14 Apr 2021 21:00 | Borussia Dortmund | 1 : 2 | Manchester City | |
| 14 Apr 2021 21:00 | Liverpool | 0 : 0 | Real Madrid | |
| 13 Apr 2021 21:00 | Chelsea | 0 : 1 | Porto | |
| 13 Apr 2021 21:00 | PSG | 0 : 1 | Bayern Munich |
| 08 Apr 2021 21:00 | Granada | 0 : 2 | Manchester United | |
| 08 Apr 2021 21:00 | Arsenal | 1 : 1 | Slavia Praha | |
| 08 Apr 2021 21:00 | Ajax | 1 : 2 | Roma | |
| 08 Apr 2021 21:00 | Dinamo Zagreb | 0 : 1 | Villarreal | |
| 15 Apr 2021 21:00 | Manchester United | 2 : 0 | Granada | |
| 15 Apr 2021 21:00 | Slavia Praha | 0 : 4 | Arsenal | |
| 15 Apr 2021 21:00 | Roma | 1 : 1 | Ajax | |
| 15 Apr 2021 21:00 | Villarreal | 2 : 1 | Dinamo Zagreb |
| 20 Apr 2021 20:30 | Bayern | : | Bayer 04 | |
| 21 Apr 2021 20:30 | Borussia Dortmund | : | Union Berlin | |
| 21 Apr 2021 20:30 | Hoffenheim | : | Borussia M'gladbach | |
| 20 Apr 2021 20:30 | Eintracht Frankfurt | : | Augsburg | |
| 21 Apr 2021 18:30 | Hertha BSC | : | Freiburg | |
| 20 Apr 2021 18:30 | Köln | : | RB Leipzig | |
| 21 Apr 2021 20:30 | Werder | : | Mainz 05 | |
| 20 Apr 2021 20:30 | Arminia | : | Schalke 04 | |
| 21 Apr 2021 20:30 | Stuttgart | : | Wolfsburg |
| 18 Apr 2021 14:30 | Arsenal | 1 : 1 | Fulham | |
| 21 Apr 2021 21:15 | Aston Villa | : | Manchester City | |
| 20 Apr 2021 21:00 | Chelsea | : | Brighton | |
| 16 Apr 2021 21:00 | Everton | 2 : 2 | Tottenham Hotspur | |
| 19 Apr 2021 21:00 | Leeds United | 1 : 1 | Liverpool | |
| 22 Apr 2021 21:00 | Leicester City | : | West Bromwich Albion | |
| 18 Apr 2021 17:00 | Manchester United | 3 : 1 | Burnley | |
| 17 Apr 2021 13:30 | Newcastle United | 3 : 2 | West Ham United | |
| 17 Apr 2021 16:00 | Southampton | : | Crystal Palace | |
| 17 Apr 2021 21:15 | Wolverhampton | 1 : 0 | Sheffield United |
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