| 16 Jan 2021 21:00 | Angers SCO | : | PSG | |
| 16 Jan 2021 17:00 | Olympique Marseille | : | Nîmes |
| 16 Jan 2021 15:30 | Borussia Dortmund | : | Mainz 05 | |
| 16 Jan 2021 15:30 | Hoffenheim | : | Arminia | |
| 16 Jan 2021 15:30 | Wolfsburg | : | RB Leipzig | |
| 16 Jan 2021 15:30 | Köln | : | Hertha BSC | |
| 16 Jan 2021 15:30 | Werder | : | Augsburg | |
| 16 Jan 2021 18:30 | Stuttgart | : | Borussia M'gladbach |
| 16 Jan 2021 18:30 | Fulham | : | Chelsea | |
| 16 Jan 2021 16:00 | Leeds United | : | Brighton | |
| 16 Jan 2021 21:00 | Leicester City | : | Southampton | |
| 16 Jan 2021 16:00 | West Ham United | : | Burnley | |
| 16 Jan 2021 13:30 | Wolverhampton | : | West Bromwich Albion |
| 16 Jan 2021 15:00 | Bologna | : | Hellas Verona | |
| 16 Jan 2021 20:45 | Sampdoria | : | Udinese | |
| 16 Jan 2021 18:00 | Torino | : | Spezia |
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