| 07 May 2021 21:00 | Lens | : | Lille |
| 07 May 2021 20:30 | Stuttgart | : | Augsburg |
| 07 May 2021 18:30 | Hannover 96 | : | Darmstadt 98 | |
| 07 May 2021 18:30 | Holstein Kiel | : | FC St. Pauli |
| 07 May 2021 21:00 | Leicester City | : | Newcastle United |
| 07 May 2021 21:00 | Real Sociedad | : | Elche |
| 07 May 2021 22:15 | Boavista | : | Tondela | |
| 07 May 2021 20:00 | FC Famalicão | : | CD Santa Clara |
| 07 May 2021 20:00 | Sparta Rotterdam | : | Vitesse |
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