| 22 Nov 2020 12:00 | CSKA Moscow | 1 : 1 | Sochi | |
| 22 Nov 2020 17:00 | Rubin Kazan | 0 : 2 | Rostov | |
| 22 Nov 2020 14:30 | Rotor Volgograd | 0 : 0 | Ural |
| 22 Nov 2020 17:00 | Angers SCO | 0 : 1 | Olympique Lyonnais | |
| 22 Nov 2020 15:00 | Dijon | 0 : 1 | Lens | |
| 22 Nov 2020 21:00 | Lille | 4 : 0 | Lorient | |
| 22 Nov 2020 15:00 | Montpellier | 4 : 3 | Strasbourg | |
| 22 Nov 2020 13:00 | Nantes | 1 : 1 | Metz | |
| 22 Nov 2020 15:00 | Reims | 0 : 1 | Nîmes |
| 22 Nov 2020 15:30 | Freiburg | 1 : 3 | Mainz 05 | |
| 22 Nov 2020 18:00 | Köln | 1 : 2 | Union Berlin |
| 22 Nov 2020 13:00 | Fulham | 2 : 3 | Everton | |
| 22 Nov 2020 17:30 | Leeds United | 0 : 0 | Arsenal | |
| 22 Nov 2020 20:15 | Liverpool | 3 : 0 | Leicester City | |
| 22 Nov 2020 15:00 | Sheffield United | 0 : 1 | West Ham United |
| 22 Nov 2020 21:00 | Deportivo Alavés | 2 : 2 | Valencia | |
| 22 Nov 2020 14:00 | Eibar | 0 : 0 | Getafe | |
| 22 Nov 2020 16:15 | Cádiz | 0 : 1 | Real Sociedad | |
| 22 Nov 2020 18:30 | Granada | 1 : 3 | Real Valladolid |
| 22 Nov 2020 12:30 | Fiorentina | 0 : 1 | Benevento | |
| 22 Nov 2020 15:00 | Internazionale | 4 : 2 | Torino | |
| 22 Nov 2020 20:45 | Napoli | 1 : 3 | Milan | |
| 22 Nov 2020 15:00 | Roma | 3 : 0 | Parma | |
| 22 Nov 2020 15:00 | Sampdoria | 1 : 2 | Bologna | |
| 22 Nov 2020 18:00 | Udinese | 1 : 0 | Genoa | |
| 22 Nov 2020 15:00 | Hellas Verona | 0 : 2 | Sassuolo |
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