| 03 Jan 2021 18:00 | Bayern | 5 : 2 | Mainz 05 | |
| 03 Jan 2021 15:30 | Borussia Dortmund | 2 : 0 | Wolfsburg |
| 03 Jan 2021 00:00 | Burnley | : | Fulham | |
| 03 Jan 2021 17:30 | Chelsea | 1 : 3 | Manchester City | |
| 03 Jan 2021 15:15 | Newcastle United | 1 : 2 | Leicester City |
| 03 Jan 2021 16:15 | Deportivo Alavés | : | Atletico Madrid | |
| 03 Jan 2021 14:00 | Athletic Club | 1 : 0 | Elche | |
| 03 Jan 2021 18:30 | Eibar | : | Granada | |
| 03 Jan 2021 21:00 | Huesca | : | Barcelona | |
| 03 Jan 2021 18:30 | Real Sociedad | : | Osasuna |
| 03 Jan 2021 15:00 | Atalanta | 5 : 1 | Sassuolo | |
| 03 Jan 2021 18:00 | Benevento | 0 : 2 | Milan | |
| 03 Jan 2021 15:00 | Cagliari | 1 : 4 | Napoli | |
| 03 Jan 2021 15:00 | Fiorentina | 0 : 0 | Bologna | |
| 03 Jan 2021 15:00 | Genoa | 1 : 1 | Lazio | |
| 03 Jan 2021 12:30 | Internazionale | 6 : 2 | Crotone | |
| 03 Jan 2021 20:45 | Juventus | 4 : 1 | Udinese | |
| 03 Jan 2021 15:00 | Parma | 0 : 3 | Torino | |
| 03 Jan 2021 15:00 | Roma | 1 : 0 | Sampdoria | |
| 03 Jan 2021 15:00 | Spezia | 0 : 1 | Hellas Verona |
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