| 17 Jan 2021 13:00 | Brest | : | Rennes | |
| 17 Jan 2021 17:00 | Lille | : | Reims | |
| 17 Jan 2021 15:00 | Lorient | : | Dijon | |
| 17 Jan 2021 21:00 | Olympique Lyonnais | : | Metz | |
| 17 Jan 2021 15:00 | Nantes | : | Lens | |
| 17 Jan 2021 15:00 | Nice | : | Bordeaux | |
| 17 Jan 2021 15:00 | Strasbourg | : | Saint-Etienne |
| 17 Jan 2021 15:30 | Bayern | : | Freiburg | |
| 17 Jan 2021 18:00 | Eintracht Frankfurt | : | Schalke 04 |
| 17 Jan 2021 00:00 | Aston Villa | : | Everton | |
| 17 Jan 2021 17:30 | Liverpool | : | Manchester United | |
| 17 Jan 2021 20:15 | Manchester City | : | Crystal Palace | |
| 17 Jan 2021 15:00 | Sheffield United | : | Tottenham Hotspur |
| 17 Jan 2021 18:00 | Atalanta | : | Genoa | |
| 17 Jan 2021 15:00 | Crotone | : | Benevento | |
| 17 Jan 2021 20:45 | Internazionale | : | Juventus | |
| 17 Jan 2021 12:30 | Napoli | : | Fiorentina | |
| 17 Jan 2021 15:00 | Sassuolo | : | Parma |
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