| 30 Jan 2021 15:30 | Bayern | : | Hoffenheim | |
| 30 Jan 2021 15:30 | Borussia Dortmund | : | Augsburg | |
| 30 Jan 2021 18:30 | RB Leipzig | : | Bayer 04 | |
| 30 Jan 2021 15:30 | Eintracht Frankfurt | : | Hertha BSC | |
| 30 Jan 2021 15:30 | Union Berlin | : | Borussia M'gladbach | |
| 30 Jan 2021 15:30 | Werder | : | Schalke 04 |
| 30 Jan 2021 16:00 | Arsenal | : | Manchester United | |
| 30 Jan 2021 16:00 | Brighton | : | Tottenham Hotspur | |
| 30 Jan 2021 16:00 | Chelsea | : | Burnley | |
| 30 Jan 2021 16:00 | Crystal Palace | : | Wolverhampton | |
| 30 Jan 2021 16:00 | Everton | : | Newcastle United | |
| 30 Jan 2021 16:00 | Leicester City | : | Leeds United | |
| 30 Jan 2021 16:00 | Manchester City | : | Sheffield United | |
| 30 Jan 2021 16:00 | Southampton | : | Aston Villa | |
| 30 Jan 2021 16:00 | West Bromwich Albion | : | Fulham | |
| 30 Jan 2021 16:00 | West Ham United | : | Liverpool |
| 30 Jan 2021 20:45 | Internazionale | : | Benevento | |
| 30 Jan 2021 15:00 | Crotone | : | Genoa | |
| 30 Jan 2021 18:00 | Sampdoria | : | Juventus | |
| 30 Jan 2021 15:00 | Bologna | : | Milan | |
| 30 Jan 2021 15:00 | Cagliari | : | Sassuolo |
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