| 09 Apr 2021 21:00 | Metz | 0 : 2 | Lille |
| 09 Apr 2021 20:30 | Arminia | 1 : 0 | Freiburg |
| 09 Apr 2021 18:30 | Hamburger SV | 1 : 2 | Darmstadt 98 | |
| 09 Apr 2021 18:30 | SpVgg Greuther Fürth | : | SV Sandhausen |
| 09 Apr 2021 21:00 | Fulham | 0 : 1 | Wolverhampton |
| 09 Apr 2021 21:00 | Huesca | 3 : 1 | Elche |
| 09 Apr 2021 21:00 | Portimonense | 3 : 0 | Vitória SC |
| 09 Apr 2021 20:00 | Vitesse | 0 : 0 | ADO Den Haag |
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