| 17 Apr 2021 13:00 | Angers SCO | : | Rennes | |
| 17 Apr 2021 17:00 | Olympique Marseille | : | Lorient |
| 17 Apr 2021 15:30 | Borussia M'gladbach | : | Eintracht Frankfurt | |
| 17 Apr 2021 18:30 | Bayer 04 | : | Köln | |
| 17 Apr 2021 15:30 | Wolfsburg | : | Bayern | |
| 17 Apr 2021 15:30 | Freiburg | : | Schalke 04 | |
| 17 Apr 2021 15:30 | Union Berlin | : | Stuttgart | |
| 17 Apr 2021 15:30 | Augsburg | : | Arminia |
| 17 Apr 2021 13:30 | Newcastle United | : | West Ham United | |
| 17 Apr 2021 00:00 | Southampton | : | Crystal Palace | |
| 17 Apr 2021 16:00 | Wolverhampton | : | Sheffield United |
| 17 Apr 2021 18:00 | Sassuolo | : | Fiorentina | |
| 17 Apr 2021 20:45 | Cagliari | : | Parma | |
| 17 Apr 2021 15:00 | Crotone | : | Udinese | |
| 17 Apr 2021 15:00 | Sampdoria | : | Hellas Verona |
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